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Women who are pregnant or who are trying to become pregnant and those who are breastfeeding should talk with their doctors about limiting caffeine use. Experienced users have described the focusing effects as being an extension of wakefulness. After about 20 hours, your executive functions (abstract and creative thinking, long and short-term memory etc.) suffer as they normally would if you were sleep provigil24h.com/smart-drugs-what-are-they-and-do-they-really-work/ deprived, even though you might still not feel any fatigue. Not everyone’s game to take a prescription drug for cognition. Racetams and microdoses of nicotine offer similar benefits to modafinil. Make sure you dose as early as possible; as soon as you wake up, and never after midday. Unless you are planning on staying up all night, which we don’t recommend as it will affect your sleep cycle and have knock-on effects on your health. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.